The motor domains of ABC-transporters
نویسندگان
چکیده
منابع مشابه
ABC Transporters Have Four Core Domains
domains, the nucleotide binding domains (NBDs), but which have evolved to couple the energy released by binding and hydrolysis of ATP to processes other than transbilayer transport. These include proteins involved in chromatin organization (13), DNA repair, telomere maintenance (15, 44), and mRNA trafficking through the nuclear pore (23). The molecular mechanism described below for ATP catalysi...
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ABC (ATP-binding cassette) transporters are primary active membrane proteins that translocate solutes (allocrites) across lipid bilayers. The prototypical ABC transporter consists of four domains: two cytoplasmic NBDs (nucleotide-binding domains) and two TMDs (transmembrane domains). The NBDs, whose primary sequence is highly conserved throughout the superfamily, bind and hydrolyse ATP to power...
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Mitochondria are essential organelles of most eukaryotic cells including fungi, invertebrates, vertebrates and plants. They perform various processes such as oxidative phosphorylation, the tricarboxylic acid cycle, fatty acid oxidation, the biosynthesis of various amino acids, the generation of iron-sulfur (Fe/S) clusters and their insertion into apoproteins, as well as partial reactions of hem...
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The set of proteins found in the membranes of mammalian peroxisomes includes four half ABC transporters (ALDP, ALDR, PMP70, P70R) comprising a distinct subset of the superfamily of ABC transporters designated subfamily D. Each has an N-terminal hydrophobic transmembrane domain with multiple transmembrane segments (TMS) and a hydrophilic C-terminal half containing a nucleotide-binding domain (NB...
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The ABC transporters (also called traffic ATPases) make up a large superfamily of proteins which share a common function and a common ATP-binding domain. ABC transporters are classified into three major groups: bacterial importers (the periplasmic permeases), eukaryotic transporters, and bacterial exporters. We present a comprehensive review of the bacterial ABC exporter group, which currently ...
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ژورنال
عنوان ژورنال: Naunyn-Schmiedeberg's Archives of Pharmacology
سال: 2006
ISSN: 0028-1298,1432-1912
DOI: 10.1007/s00210-005-0031-4